10GBe tuning for best throughput between NAS and workstation

Please don’t discount large files. Why not large files? Its 2021, I transfer 80GB files or 300GB often enough.
It depends how you use it, it shouldnt matter if its 5MB or 300GB or more, this is not being helpful.

As a technical exercise I am going to be trying to see what I can get out of the CX-3 cards over 40Gb switch - routed